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Hemostasis in Wound Healing ClotFoam formulations: From the prevention of hemorrhage to faster and better wound healing and collagen formation |
Incisions created by a scalpel or trauma resulting from a bullet, all undergo a similar and predictable reparative process. The first task is to stop the bleeding and close the wound within minutes to hours of its creation. This initial response controls hemorrhage. After a short period, cells migrate to the wound bed. Platelets, the first responders release multiple chemokines that stabilize the wound through clot formation.
The second stage is the proliferative phase. Epithelialization, angiogenesis, granulation tissue formation, and collagen deposition are the principal tasks of the body in this anabolic portion of wound healing. Sometimes, the wound closes spontaneously by contraction and reepithelialization. Often it does not, requiring closure with suturing or by another mechanism.
Finally, the wound undergoes contraction, turning into a scar. The entire process is a dynamic continuum with an overlap of each phase and continued remodeling, reaching its maximal strength at one year. Hemostatic agents, sealants and wound dressings help ensure an acceptable outcome from surgery, and assist the body in repairing damaged tissue.
Biomedica has developed a 2nd-generation wound healing platform technology that covers the wound healing process from hemorrhage to scar formation.
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Combat Casualty Care